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We delineated somatic mutations (high and moderate impact defined by SnpEff [21]) associated with a SBS5 dominated mutational landscape and identified BRCA2 and ERCC2 mutated tumors to be significantly enriched for SBS5 mutations (p = 0.0003, p = 0.00003, respectively; permutation test; Fig. 2c), together with a few other genes like ABCA6, TEP1, and BOD1L1 (p = 0.00078, p = 0.00085, p = 0.00168, respectively; permutation test; Fig. 2c).
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