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  • For patients responding to chemotherapy, we observed a significantly higher number of indels (p = 0.031; SNVs: p = 0.38; neoantigens: p = 0.17; Wilcoxon rank-sum test; Fig. 1b-d) and a significantly higher proportion of the genome under allelic imbalance (SNP arrays (n = 49); p = 0.024; Wilcoxon rank-sum test; Fig. 1e), indicating that a more disrupted genome is more sensitive to treatment with chemotherapy.
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