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  • Our analysis of COVID-19 in children until the end of May 2020 indicated mortality was rare and lower than from influenza, for which children already have a vaccine. We feared and wrote that over time the severity of the virus in children might increase. We published this in May 2020 and now examine childhood mortality from COVID-19 over time and compared with other causes in seven countries: the USA, United Kingdom, Italy, Germany, Spain, France and Republic of Korea. As before, we extracted COVID-19 mortality data for 0-to-19-year olds (only data for 0-to-14-years old group were available in the USA) from The National Institute of Demographic Studies, which is collated from national statistical agency reports. This analysis was for five months between 1 March 2020 until 31 July 2020 (5 months). We extracted mortality data for other- and all-causes from the latest Global Burden of Disease estimates (2017) except for influenza deaths which we obtained for the last three years from national statistical agencies. We estimated deaths from these annual data for the five-month period through simple division (5/12) of the annual numbers. B.O., S.S.B. and J.B. cross-checked all data. In an estimated population of 137,047,945 from March to July, there were 78 deaths due to COVID-19. For comparison, there were an estimated 21,966 deaths from all-causes (1755 from unintentional injury, 510 from lower respiratory tract infection, 178 from influenza), with COVID-19 accounting for 0.355% of deaths (Table 1 & Fig. 1 ). We examined mortality weekly, finding that the peak of cases and deaths in children mainly matched that of adults (the USA continues to report child deaths from COVID-19 which is in line with the continuation of that country's overall epidemic) (Fig. 2 ). The proportion of deaths attributable to COVID-19 in children was stable over May, June and July. We predict this proportion will decline assuming the continuation of public health control measures and improvements in treatments.Mortality for the USA, United Kingdom, Italy, Germany, Spain, France and South Korea in 0-to-9 and 10-to-19-year-olds (0-4y and 5-14y in the USA) from all-causes, unintentional injury, lower respiratory tract infection, influenza and COVID-19 with estimated absolute numbers and mortality per 100,000 population. Five months of data show that in these countries, children are at much greater risk of death from other elements of normal life, than from COVID-19. Our fears of increased virulence in children, so far, are unfounded. Nonetheless, vigilance is necessary as the pandemic may unfold differently. Children were hit hard by the 1918-1919 influenza pandemic and were key to spread of that disease; this, fortunately, does not so far appear to be the case with COVID-19. Close monitoring is essential after relaxation of ‘lockdown’ policies, particularly as there are genetic changes in the virus. Children have sacrificed much to international efforts to contain COVID-19. We know that negative experiences in childhood matter lifelong. Cases, hospitalisations and deaths due to COVID-19 may increase during the northern hemisphere winter. If this happens, we must remember the minimal direct risk to children of COVID-19 and to act to minimise the harmful effects of future lockdown measures - including school closures - on children especially those without good evidence of likely efficacy. Our data have implications for quantitatively demonstrating the safety and effectiveness of potential vaccines in children and planning for vaccination should a safe and effective vaccine be invented.
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