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  • Many of the HIF-dependent proteins are involved in oxygen sensation and regulation and include genes involved in the uptake and metabolism of glucose (GLUT-1, 6-PFK, PDK), angiogenesis (VEGF, PDGF, CTGF), control of extracellular pH (CA9), mitogenesis (TGFα), and erythropoiesis (erythropoietin) [20-23].
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