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Four Pt(II) complexes: [PtCl(DACHEX)], [PtI(DACHEX)], [Pt(CBDCA)(DACHEX)], and [Pt(OXA)(DACHEX)] (CBDCA = 1,1′-cyclobutanedicarboxylate, OXA = oxalate), possessing the racemic diamine carrier ligand, were synthesized and tested against a panel of human tumor cell lines, including cervical (A431), ovarian (2008), and colon carcinomas (HCT-15 and LoVo), together with two oxaliplatin-resistant clones (LoVo OXP and LoVo MDR).
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