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  • Furthermore, it was found that the 1,2-GG intrastrand crosslinks formed by kiteplatin are removed by DNA repair systems with lower efficiency than those formed by cisplatin and are more effective in inhibiting DNA polymerases such as the model prokaryotic DNA polymerase I (KF) of the A-family and the eukaryotic translesion DNA polymerase η (Pol η) of the Y-family human DNA polymerases [7,8,9].
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