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  • All Pt(IV) compounds resulted to be much more effective against human A431 cancer cell 3D spheroids than CDDP and OXP and, consistently with 2D studies, complex 3 proved to be the most effective compound, showing an efficacy (in decreasing cancer spheroid viability) of about 32 and 20 times higher than those of CDDP and OXP, respectively.
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