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In addition, CBX4 expression in cells with both miR-497-5p inhibitor and CBX4 interference RNAs (miR-497-in+SiCBX4-1 group) was decreased when compared with the control group (miR-497-inNC+NC), suggesting that silenced expression of CBX4 neutralized miR-497-5p inhibitor induced up-regulation of CBX4 (Figure 4B).
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