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  • As depicted in Figure 2B, insulin resistance was observed in all disease models, as the constant rate for glucose disappearance (K) significantly decreased when compared to their correspondent age-matched controls, except for the HF+STZ group, (HF 3 weeks = 2.07 ± 0.19; HF 19 weeks = 1.97 ± 0.29; HF+STZ = 5.01 ± 0.18; HSu 4 weeks = 2.45 ± 0.25; HSu 16 weeks = 1.79 ± 0.19; HFHSu 25 weeks = 1.82 ± 0.13; Zucker 17 weeks = 1.55 ± 0.47 Zucker 23 weeks = 1.59 ± 0.33; CTL 3 weeks = 4.56 ± 0.41; CTL 19 weeks = 4.32 ± 0.26; CTL for HF+STZ group = 4.17 ± 0.31; CTL 4 weeks = 4.56 ± 0.41; CTL 16 weeks = 5.29 ± 0.51; CTL 25 weeks = 4.73 ± 0.30; lean 17 weeks = 4.46 ± 0.49; lean 23 weeks = 4.22 ± 0.00% glucose/min).
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