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  • Studies on one of these individuals who had received a red blood cell transfusion from a 129MM donor showed no evidence of abnormal PrP in the brain but deposition in the spleen and a cervical lymph node was observed (Peden et al., 2004) and using protein misfolding cyclic amplification (PMCA), prion seeding potential was demonstrated in a range of tissues (Bougard et al., 2016).
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