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  • Conserved sequences as short as six to eight nucleotides in length may provide an opportunity for microRNA binding (Brennecke et al. 2005; Krek et al. 2005; Lewis et al. 2005) We identified invariant codons to exist throughout our alignments of duplicated genes and at times these invariant codons were clustered in groups of as many as 10 invariant codons (30 identical nucleotides) raising the possibility that some duplicates may be regulated by microRNAs.
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