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  • To address these challenges, we have developed a new software framework called COBRAme for building and simulating ME-models. We used COBRAme to reconstruct a condensed E. coli ME-model called iJL1678b-ME. We addressed these challenges by developing a computational framework called COBRAme for building, editing, simulating, and interpreting ME-models. COBRAme is written in Python and extends the widely used COBRApy software that only supports M-models [18]. The latest version of COBRAme can be downloaded from https://github.com/SBRG/cobrame.
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