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  • While the electrons with the donating group, such as methoxy groups-especially at position 3, 4 or 3, 5 and 2, 4, 6, as in compounds 5, 6, 8, 10, 11, cause rich in nucleophilicity and resonate the α,β-unsaturated carbonyl [41], eventually, the structure become less effective and binding or the interaction with the Michael receptor (nucleophile), and the compounds reduce the cytotoxic effects [38,39]. 2.3.
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