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While the reason for this discepency is unknown, increased complexities concerning estrogen regulation of GC secretion (Bangasser and Valentino, 2014; Toufexis et al., 2014), diurnal rhythms, and the age of patients tested (Veldhuis et al., 2013) may need to be controlled more carefully, as such conditions may strongly influence the difference in GC secretion in women compared to men (Kudielka and Kirschbaum, 2005).
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