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  • Indeed, multiple pre-clinical studies support elevated cAMP/PKA signaling in the prefrontal cortex and hippocampus of AD mouse models (Choi et al., 2006; da Cruz e Silva et al., 2009; de Barry et al., 2010; Kim et al., 2011; Lee et al., 2004; Nelson et al., 2009; Takashima, 2006; Thathiah and De Strooper, 2011; Thathiah et al., 2013).
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