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  • CRF overexpression in the forebrain can lead to accumulation of Aβ and hyperphosphorylated tau through CRF1-Gs-PKA, consistent with this pathway's role in influencing the amyloid production cascade through modulation of α-, β- and γ secretases (Park et al., 2015; Robert et al., 2001; Thathiah and De Strooper, 2011; Thathiah et al., 2013; Xu et al., 1996).
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