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  • In terms of GC effects on AD pathogenesis, administration of the corticosteroid dexamethasone to APP/PS1/MAPT mice increases APP and Aβ levels as well as β-secretase (BACE) and the β-C-Termial Fragment (β-CTF) of APP, suggesting a direct role between GC signaling and AD pathogenesis (Green et al., 2006).
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