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  • Of these different signaling pathways, central CRF/CRF1 signaling in areas like the amygdala, hippocampus, prefronal cortex, locus coeruleus (LC), and dorsal raphe (DR) have been shown to have a major impact on behavior (Blank et al., 2002, 2003; Gallagher et al., 2008; Orozco-Cabal et al., 2006).
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