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  • Trials were excluded if they included patients with: (1) DSM-IV diagnosis of major depressive disorder, bipolar disorder, or other psychotic disorders within the past 6 months; (2) use of any neuroleptic, antidepressant, or anxiolytic agent in the two weeks before data collection at baseline; (3) history of alcohol or any psychoactive substance abuse or dependence (as defined by DSM-IV) within the past 6 months; (4) risk of suicide; (5) previous treatment with duloxetine before randomization.
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