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To accommodate for the respective weaknesses of anatomically and functionally defined ROIs, we here applied a combined approach, which is based on both anatomical and functional constraints, for the definition of frontal and parietal ROIs as described in Adcock et al. (2003) [40] and Jansen et al. For the frontal ROI, group level activation patterns were thresholded as follows: “dots-in-space” and mental rotation task with p < 0.001 uncorrected, k = 50; Landmark task version A, B and C with p < 0.01 uncorrected, k = 50 (version A) and k = 20 (Version B and C), reflecting the functional constraint.
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