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  • Secondary outcomes were the following: Global assessment of eczema by research nurses (Investigator Global Assessment [IGA]) [19] and by participants (participant global assessment [PGA]) at baseline, 2, 4, and 6 mo, using a six-point scale (clear, almost clear, mild, moderate, severe, very severe).Self-reported eczema symptoms using the HOME-recommended core outcome instrument [15], the Patient Oriented Eczema Measure (POEM), which captures frequency of itch, sleep loss, bleeding, weeping/oozing, cracking, flaking, and dryness [20].
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