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  • This decision was based on the results from 2012 (see Table 2), which showed that 1) the values generated by the 11β-hydroxyetiocholanolone and 11oxo-etiocholanolone assays correlated strongly with each other for each of the 5 tested individuals (all r = 0.71–0.98; p < 0.0001) thus providing very similar response patterns to adrenocortical stimulation, 2) time lags of responses were identical for the two assays, but 3) peak increase in levels in response to the challenge was, on average, twice as large (13.6 vs. 6.1 fold) for 11β-hydroxyetiocholanolone than for 11oxo-etiocholanolone, indicating a higher sensitivity of the former to stressful events.
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