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All experiments were conducted in accordance with international standards of animal welfare recommended by the Brazilian Law (#11.794–10/08/2008) and Animals (Scientific Procedures) Act 1986, with experimental protocols approved by the Committee for Ethics in Animal Research of the Federal University of Santa Catarina (CEUA-UFSC #23080.025621/2009-03) and Home Office License 30/2512 (UK).
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