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  • 9) The defensin experiments (subsection “Protease-Mediated Disruption of Plasma Membrane Integrity Leads to Embryo Death” et seq.) are interesting, but are not judged to be extensive or definitive enough, to justify the conclusion that oviductal innate immune suppression mediated by Esr1 signaling is required for fertilization and preimplantation embryo development.
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