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According to age at onset, two main types of AD are differentiated: Early-Onset AD (EOAD, appears generally before the age of 65, less than 10% of the AD population and clear genetic determinants with mutations found in the APP, PSEN1 and PSEN2 genes) and Late-Onset AD (LOAD, more than 90% of the AD population, appears generally after the age of 65 and has a complex etiology based on genetic and environmental factors) [28].
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