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  • 0 (xsd:integer)
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  • 470 (xsd:integer)
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  • By assuming an additive mode of inheritance (RR1=RR2+12), and using f0 = Kp/(p0 + RR1 × p1 + RR2 × p2), f1 = RR1 × f0, f2 = RR2 × f0 and the Bayes formulas, we can easily derive the desired frequencies: {(pD0,pD1,pD2)=(f0×p0Kp,f1×p1Kp,f2×p2Kp)(pH0,pH1,pH2)=((1-f0)×p0Kp,(1-f1)×p1Kp,(1-f2)×p2Kp) The 24 SNPs are simulated independently according to this model, the 12 non-associated SNPs with a relative risk of 1 and the 12 DSLs with a relative risk ranging from 1 to 2.
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