This suggests that these cells can at least partially respond to Hedgehog signaling, though the in-vivo consequences of persistent altered GLI3FL to GLI3R amounts in certain tissues, particularly in a temporal manner, may underlie developmental abnormalities, particularly polydactyly, as seen in these SRPS cases.
![[This page as RDF]](http://data.gesis.org/somesci/static/rdf-icon.gif){kind=icon}