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  • As for the interaction between CB and other TKIs [28], CB binds to pazopanib with an affinity of 13.49 nM, thus forming a complex displaying a total intermolecular energy of −85.20 kcal/mol (E= −79.14 kcal/mol; E = −6.06 kcal/mol) (Supplementary Fig. 2 A, B).
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