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  • We found that sorafenib at 10 μM and 20 μM (Supplementary Figure 1) induces dose-dependent apoptosis of both 5637 and T24 BC cells, with 20 μM showing higher apoptotic effects compared with dose 10 μM; the 20 μM sorafenib-induced effect started at 12 h (% apoptotic cells: 52% and 62% in 5637 and T24 BC cells, respectively) and was maximal at 24 h after treatment (% apoptotic cells: 60% and 78% in 5637 and T24 BC cells, respectively) (Fig. 1C and supplementary Fig S1).
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