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  • As a large proportion of the variables did not follow the normal distribution, we used the Kruskal-Wallis test (P ) to test the intergroup differences, Mann-Whitney U test (P ) to test the pairwise intergroup differences (placebo versus 40 μg/d and placebo versus 80 μg/d), and the Jonckheere-Terpstra test (P ) for trend across the groups.
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