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The insulinogenic index (IGI) was computed as follows: IGI = (30 min insulin − 0 min insulin)/(30 min glucose − 0 min glucose) in the OGTT, as described by Phillips and coworkers [16], and the insulin sensitivity index (ISI) was computed as follows: ISI = 10000/Sqr[(fasting glucose × fasting insulin) × (mean glucose × mean insulin)], as described by Matsuda and DeFronzo [17].
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