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As indicated by sharing of the bond index “1” by the mtor and FRB components on the right-hand side of the rule in Equation (1), rapamycin* binds the FRB domain in MTOR. (Bond indices are prefixed by an exclamation mark.) Inclusion of the HEAT component in the left-hand side of Equation (1) without specification of a binding partner indicates that this component must be free in order for the rule to be applicable.
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