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  • The reaction network consists of 173 chemical species and 6,581 unidirectional reactions. (The size of the reaction network reflects the number of protein phosphoforms and protein complexes that can arise from the interactions represented by the rules of the model.) BioNetGen’s built-in ODE solver, CVODE from the SUNDIALS package [69], was then used to numerically integrate the ODEs, using default settings.
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