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  • AMPK phosphorylates ULK1 at S317 and S778: We represent AMPK-mediated activating phosphorylation of ULK1 at S317 and S778 using two unidirectional rules, as follows: AMPK(ulk1!1,T172~P,ST~0).ULK1(stampk!1,straptor,S317~0)-> \AMPK(ulk1!1,T172~P,ST~0).ULK1(stampk!1,straptor,S317~P)p7(11A) AMPK(ulk1!1,T172~P,ST~0).ULK1(stampk!1,S778~0)-> \AMPK(ulk1!1,T172~P,ST~0).ULK1(stampk!1,S778~P)p8(11B) where p7 and p8 are (pseudo first-order) rate constants.
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