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  • Recall that S65 and T70 in EIF4EBP1 are represented, for simplicity, as a single component named S65_T70. (See the molecule type definition for EIF4EBP1.) ULK1 phosphorylates RPTOR at S792, S855, and S859: We represent ULK1-mediated inhibitory phosphorylation of S792, S855, and S859 in RPTOR using three unidirectional rules, as follows: RPTOR(ulk1!1,S792~0).ULK1(straptor!1,S317~P,S778~P)-> \RPTOR(ulk1!1,S792~P).ULK1(straptor!1,S317~P,S778~P)p3(8A) RPTOR(ulk1!1,S855_S859~0).ULK1(straptor!1,S317~P,S778~P)-> \RPTOR(ulk1!1,S855_S859~P).ULK1(straptor!1,S317~P,S778~P)2*p4(8B) RPTOR(ulk1!1,S855_S859~P).ULK1(straptor!1,S317~P,S778~P)-> \RPTOR(ulk1!1,S855_S859~PP).ULK1(straptor!1,S317~P,S778~P)p4(8C) where p3 and p4 are (pseudo first-order) rate constants.
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