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  • MTORC1 phosphorylates ULK1 at S758: We represent MTORC1-mediated inhibitory phosphorylation of ULK1 at S758 using a unidirectional rule, as follows: MTOR(HEAT!1).RPTOR(WD40!1,ulk1!2).ULK1(straptor!2,stampk,S758~0)-> \MTOR(HEAT!1).RPTOR(WD40!1,ulk1!2).ULK1(straptor!2,stampk,S758~P)p1(6) where p1 is a (pseudo first-order) rate constant.
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