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  • In this period, the maternal immune system must develop a tolerance to paternal alloantigens in order to prevent maternal immune aggressions against the foetus and maintain active immunity against infectious agents to protect both the mother and foetus [20] For this reason, during pregnancy, the T helper 1 (Th1) associated cellular immune response is repressed and Th2-type immunity is stimulated in response to pathogens [21], [22].
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