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The mature neurotoxic conopeptide κA-conotoxin SIVA (κA-SIVA, also called s4a) isolated from its venom has been shown to be active on tetrodotoxin-sensitive voltage-gated sodium (Na) channels [53]-though not on voltage-gated potassium channels as thought earlier [54]-thus eliciting spastic paralytic symptoms when injected into the fish during prey capture.
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