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  • Nicotine and cotinine pharmacokinetics in neonates exposed in utero to nicotine had significantly longer nicotine t in the infants’ serum than that reported for adults (neonates t nicotine=11.2 h (95% CI 8.0 to 18.9 h); adults t nicotine=approximately 2 h) with no differences for cotinine [29], suggesting that differences in the nicotine t but not in the cotinine t between neonates and adults may relate to differences in nicotine metabolism [65].
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