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  • Remarkably, cyclin-dependent Kinase inhibitor (CDKN1A or p21), which functions as a regulator of cell cycle progression at G1, was significantly upregulated (Fold change 2.6, p value <0.02) and this was validated by immunohistochemistry showing higher percentage of p21 positive cells in the combined arm in vivo (66% vs 15%, p<0.001) (Figure 5A) as well as in vitro (Figure 5B).
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