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Standard Michaelis-Menten equation of BChE-catalyzed cocaine hydrolysis was used for a couple of reasons: (1) BChE-catalyzed hydrolysis of cocaine is the dominant cocaine-metabolizing pathway in plasma and the other cocaine-metabolizing pathways may be neglected [10]; (2) the products of BChE-catalyzed hydrolysis of cocaine do not significantly inhibit BChE [38].
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