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  • A two-compartment in vivo pharmacokinetic model (Figure 1) with Michaelis-Menten elimination in plasma was built to describe the cocaine concentration-time profile in the human body and characterize the relationship between the profile and the observed pharmacological activity of cocaine reported by Fowler et al. [37] Assuming that all compartments are homogeneous, the model is based on the following differential equations:(1)(2)where and represent the cocaine concentrations in plasma (compartment 1) and brain (compartment 2), respectively.
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