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  • The V3 loop is topographically divided into three subsections (Figure 2): 1) The base, formed by a disulfide bond and in close approximation with the gp120 core; 2) the stem, which is a flexible linker region between the base and the tip; 3) the crown, which contains a helix-turn-helix motif defined by a G-P-G-X sequence, and believed to be a critical interacting face with the extracellular loops of CCR5.
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