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Large susceptibility variations in primary HIV-1 isolates have been documented for the chemokine derivative AOP-RANTES [148], the fusion inhibitor enfuvirtide (ENF, T-20) [102,103,149], and many small molecule coreceptor antagonists [TAK-779 [102,150], maraviroc [128], SCH-C [150], vicriviroc [151], and AMD-3100 [149].
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