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  • HIV-1 entry inhibitors fall into three major classes based on the specific entry process that they target: 1) attachment inhibitors, which block the interaction between HIV-1 envelope and CD4, 2) coreceptor inhibitors, which block the interaction between HIV-1 envelope and CCR5 or CXCR4, and 3) fusion inhibitors, which prevent the virus from mixing its membrane with the host cell membrane and releasing the viral core into the cytoplasm (Table 2).
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