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  • Our studies show, for the first time in adult albino Swiss mice, that lasering of the limbal tissues results in elevated IOP, which in turn induces several sequential degenerative events in the RGC layer that result in degeneration of the RGC population, with a time lapse between the first alteration in the axoplasmic flow and the delayed degeneration of the intraocular axons and their parent cell bodies; this underlines the opportunity for neuroprotective strategies to be applied within a long interval before actual RGC death and is consistent with our recent studies in adult albino rats [26].
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