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  • Transgenic mice are used in increasing numbers as experimental models for various neurodegenerative diseases [25], including the line of DBA/2 mice used as glaucomatous optic neuropathy models [3,52-57]; this, with their availability, their well characterized genome, and the relatively low cost of producing diverse genetic manipulations [58], underscores the need to characterize the effects of ocular hypertension in wild mice, as well.
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