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  • While this may be seen as a disadvantage when compared to a more chronic model of IOP elevation, our IOP profile produced a severe injury to the retina that resulted in several features - loss of RGCs and degeneration of the nerve fiber layer, for example - that are common in an inherited mouse model of ocular hypertension [54-57] commonly used to investigate mechanisms of cell death in glaucomatous optic neuropathy.
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