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  • Background: Of patients with Parkinson's disease (PD), 30% to 85% report pain. However, mechanisms underlying this pain remain unclear. In line with known neuroanatomical impairments, we hypothesized that pain in PD is caused by alterations in emotional-motivational as opposed to sensory-discriminative pain processing and that dopamine recovers the capacity for endogenous emotional-motivational pain modulation in patients with PD. Methods: A total of 20 patients with PD played a random reward paradigm with painful heat stimuli in addition to assessments of pain sensitivity once with and once without levodopa. Results: Levodopa increased endogenous pain inhibition in terms of perceived pain intensity and un/pleasantness compared with a medication off state. Higher clinical pain was associated with higher increases in pain inhibition. Levodopa did not affect heat pain threshold, tolerance, or temporal summation. Conclusion: Patients with PD seem to be predominately impaired in emotional-motivational as opposed to sensory-discriminative pain processing. A differential understanding of pain in PD is urgently needed because effective treatment strategies are lacking. (xsd:string)
?:citation
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?:dateModified
  • 2020 (xsd:gyear)
?:datePublished
  • 2020 (xsd:gyear)
?:doi
  • 10.1002/mds.28241 ()
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  • en (xsd:string)
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?:issn
  • 1531-8257 ()
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  • 12 (xsd:string)
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  • Recovery of Impaired Endogenous Pain Modulation by Dopaminergic Medication in Parkinson's Disease (xsd:string)
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  • Zeitschriftenartikel (xsd:string)
  • journal_article (en)
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  • GESIS-SSOAR (xsd:string)
  • In: Movement Disorders, 35, 2020, 12, 2338-2343 (xsd:string)
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?:urn
  • urn:nbn:de:0168-ssoar-100813-8 ()
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  • 35 (xsd:string)