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On 3 March 2017, a blog titled This Talk Ain’t Cheap published an account of a family's experience with the DIY craft phenomenon known as slime, a goo made from white glue, borax, shaving cream, and water. In the piece, titled Beware of Homemade Slime, the author recounted how her daughter had come down with a series of symptoms, including headache and respiratory problems, with no clear cause. But when they removed all the slime and slime-related products from their house, however, her daughter immediately became healthy: While we cannot speak to the specific mechanism behind the daughter’s ailment, it is not impossible that one or more ingredients of slime may contributed in some way. Everyone reacts differently to certain compounds, and sensitivity to one of the compounds present in slime is a possibility. Furthermore, if the daughter was frequently in contact with dry borax, it is possible that compound could have contributed to respiratory problems (just like any other fine particulate powder) or skin irritation. Additionally, as a solution of borax necessarily produces boric acid, improper dilution can also lead to skin irritation and even, as has been reported, serious burns. Unfortunately, the post went on to list myriad other possible health risks of slime, borrowing heavily from information presented by the British tabloid Daily Mail and other questionable sources, many of which are either completely false, or generally misleading. These claims include: Potential harm from borax There is a kernel of truth the claims made about Borax (aka sodium borate). It is indeed toxic if ingested, but an ordinarily healthy person would need to ingest a relatively large amount of it to suffer serious health effects. Some governmental bodies, including the government of Canada, have recommended against Borax's use in children's craft projects, citing concerns about the cumulative effects of long-term exposure from both natural and unnatural sources. This move likely reflects an abundance of caution. A comprehensive review of the toxicity of borate-based products in humans concluded that the doses required to create any genotoxic or acute toxic effects are absurdly unrealistic: A separate detailed review of studies on both humans and laboratory animals, concerned specifically with human developmental and reproductive toxicity, similarly concluded that The typical human exposures are below the minimum level considered to be adverse to reproduction. Additionally, the above-cited work all assumes actual consumption of borax, as it does not easily pass through unbroken skin. Considering that a) the goal is not to eat the slime, and b) the recipe calls for about 1g diluted in 20 ml of water, the use of borax in slime does not represent a realistic toxic, genotoxic, or reproductive health risk. Potential harm from Elmer’s Glue-All In the This Talk Ain’t Cheap post, the author linked to fact sheet about household glue poisoning from MedlinePlus (a program of the National Institutes of Health). That post explicitly stated that most household glues, such as Elmer's Glue-All, are not poisonous. All of the symptoms listed in the Facebook post, sourced from this fact sheet, concern glue that contains volatile organic compounds (Ethanol, Xylene, Light aliphatic naphtha, N-hexane, Toluene) that Elmer’s glue (or other white glue) does not contain. Potential harm from shaving cream To support claims that shaving cream is dangerous, the author cites a HowStuffWorks post titled Are There Harmful Chemicals in Shaving Cream? That article highlights a number of chemicals it states can cause harm, but it does so inaccurately and with misleading information: These ingredients (though not nitrosamines) are all listed as present in the commonly used Barbasol brand of shaving cream, but the statement of their risks as it relates to homemade slime is not accurate or largely misleading. The HowStuffWorks post states that Propolene [sic] glycol is a humectant like glycerin, but unlike glycerin, it's more frequently found in antifreeze and brake fluid. While using the term antifreeze is a popular scare tactic for those inclined to chemophobia, Propylene glycol is not toxic to humans in any relevant dose. While Propylene glycol is a mild skin irritant to some people, it is recognized as safe for both food and cosmetic use. With regard to Triethanolamine (TEA), that post stated It’s also a very controversial ingredient in the cosmetic industry because not only is it a skin irritant, but many formulas containing TEA are found to be contaminated with nitrosamines, which are linked to cancer. While TEA may also be a skin irritant to some (though clearly not enough to produce a massive epidemic of unshaved men), the jump to nitrosamines — which are unequivocally carcinogenic — is, again, misleading. Nitrosamines are not added to cosmetics but are instead formed when amines (a chemical commonly found in proteins) mix with a nitrosating chemical (a chemical that, generally speaking, adds a nitrate group to its chemical structure). Because nitrosamines form through natural physical processes, they occur in nature and in low quantities ubiquitously. In an effort to prevent their formation in cosmetics, governmental regulators such as the FDA and the European Union Scientific Committee on Consumer Safety have placed strict requirements to mitigate their formation and have enacted associated testing and monitoring requirements. Is it possible that there are nitrosamines in shaving cream? Yes. But if nitrosamines even in small quantities were dangerous, then one would also have to avoid, according to a 1990 review, Bacon, ham, frankfurters, sausage, cured meat products, poultry, fish, and fish products, cheese, beer, malt, grain, margarine, edible vegetable oils, water, air, and soil. Finally, the HowStuffWorks post discussed two sulphate compounds: Both SLS and SLES can, like any detergent compound that removes oil from your skin, cause irritation. The claim that SLS interacts with estrogen in humans is not found in any of the 3,155 scientific articles listed on the PubChem website for the chemical, nor in any of the 306 articles in the National Institute of Health's curated list of research related to SLS’s adverse effects. The argument regarding dioxane is similar to the nitrosamine argument above, as the compound can introduced as an impurity during synthesis of the above sulfate compounds. Its presence in many cosmetics, as well as its carcinogenicity, are not in question. However, at concentrations found even in the most egregiously contaminated shaving creams (further diluted by other slime ingredients), it would not pose a credible health risk. While we cannot rank the specific personal circumstances described in the This Talk Ain’t Cheap post, we can say that claims of other more terrifying slime-related health concerns are not rooted in reality, so long as one is not actively eating the final product or breathing copious amounts of dry borax during its production.
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